Powerful systemic enzyme therapy

Quantity Per Unit -
150: $74.99
300 capsules: $124.99

Circulatory & Inflammation Support
∙ Normal Respiratory Health
∙ Supports normal blood pressure
∙ Reduces blood platelet stickiness
∙ Healthy C-reactive protein levels
∙ Healthy response to inflammation

Serracor-NK is a powerful blend of antioxidant herbs, CoEnzyme q10 and magnesium with enteric coated serrapeptase and nattokinase, systemic enzymes studied for their fibrinolytic properties. Serracor-NK supports a healthy circulatory system and normal fibrin metabolism.

Serracor-NK™ contains the original Neprinol® formula, which contains SEBkinase® with enteric coated serrapeptase and nattokinase. We are the original manufacturer of this formula, imitated by many others. Read more at the bottom of the page.

Enteric coated Serrapeptase and Nattokinase: Why is it important?

Most nattokinase and serrapeptase brands on the market are not enteric coated, which means they can lose a significant portion of their fibrinolytic activity and effectiveness in the acidic environment of the stomach. The enteric coating of our Serracor NK SEBkinase blend allows these sensitive enzymes to survive the acidic conditions of the stomach, thus allowing them to pass into the circulatory system maintaining high activity levels.

How do Fibrinolytic Units (FU's) relate to enteric coating?

Enzyme activity measured in fibrinolytic units does not mean anything if the enzymes are destroyed and/or denatured in the high acidic conditions of the stomach. Under these conditions, our laboratory tests have consistently shown that serrapeptase and nattokinase lose significant activity when exposed to low pH (such as those in the stomach). In contrast, our enteric coated nattokinase and serrapeptase (the original SEBkinase formula) perform at greater activity levels in the same low pH conditions.

The pH resistant enteric coating will disintegrate after it enters the alkaline environment of the intestines. If your enzyme formula is not enteric coated, you may be wasting your money.

Serracor-NK for Circulatory Support

Did you know cardiovascular disease is the biggest killer in America? Arterial plaque build-up, excessive fibrin levels and metabolic waste matter slow normal blood circulation. A healthy vascular system must supply oxygenated blood to vital organs including the heart and brain.

Serracor-NK supports the body’s natural response to inflammation, normalizes fibrin levels in the circulatory system, reduces C-reactive protein levels, and normalizes blood viscosity and platelet stickiness.*

SEBkinase brings together two enteric coated, fibrinolytic proteases: Peptizyme SP® (Serrapeptase) and NattoSEB® (our Nattokinase is Vitamin K-free, since it assists in blood coagulation). Serracor NK further supports the activity of SEBkinase-CV with a complete array of proteolytic enzymes, amylase, lipase, CoQ10, herbs and minerals. The net result is a comprehensive systemic enzyme blend designed to support maximum cardiovascular health.*

Serracor-NK also promotes healthy levels of C-reactive protein, an inflammation marker and serious risk factor for cardiovascular disease.* In addition, the entire systemic enzyme blend is manufactured in a ISO 9001:2000 and GMP certified facilities using our Bioactive Protein Peptide System™ (BPPS).

Fibrin performs an important function in the body, including clotting and wound healing. However, excessive fibrin can impede normal blood flow, which may lead to increased blood viscosity, swelling, edema, pain, inflammation and more serious cardiovascular events. The proteases in Serracor-NK support normal fibrin levels, blood viscosity and overall blood circulation.*

Serracor-NK Dosage

For best results, begin enzyme regiment at a low dosage of 1 capsule three times a day. After three days, increase your Serracor-NK dosage to 2 capsules three times a day. After the first week, doses should be adjusted to a therapeutic level of 3 or more capsules three times a day (amount is dependent upon desired benefit).

NOTE: It is important to continue therapeutic doses until results are realized. This should then be reduced to a maintenance dose of 1-3 capsules three times a day.

Serracor-NK Side Effects

There appear to be no side effects when taking oral enzymes for a long-term duration. Gastrointestinal disturbances may occur in individual cases, and minor allergic reactions (reddening of the skin) are rare and only occur with high doses. Long-term usage of supplemental enzymes has not been found to be detrimental.

If you are taking anticoagulants, like warfarin type of drugs, do not take this product without consulting your physician. If you are pregnant or nursing, consult your healthcare professional before using this or any dietary supplement.

Nattokinase Research: Fibrinoyltic Activity

In vitro and in vivo studies have consistently demonstrated the potent fibrinolytic effect of Nattokinase.1 A review of the research on nattokinase demonstrates it may help avoid or reduce the likelihood of deep vein thrombosis, cardiac infarction, pulmonary emboli and stroke. It appears to accomplish this via its fibrinolytic, anti-inflammatory and modulating effect on blood pressure. Studies on hypertension demonstrate an average drop of 10.9% in systolic blood pressure and a 9.7 percent drop in diastolic blood pressure.2,3,4

A study conducted with natto on 12 healthy adults (6 men and 6 women, between the ages of 21 and 55) sought to demonstrate fibrinolytic activity. The volunteers were given 200 grams of natto (the food) before breakfast, and their fibrinolytic activity was tested over time. The results indicate natto generates an increased ability to dissolve blood clots. As a control, researchers later fed the same amount of boiled soybeans to the same volunteers and tracked their fibrinolytic activity. The tests showed no significant change.5

The accumulation of fibrin in blood vessels significantly increases the likelihood of thrombosis formation resulting in a cardiovascular event. For thrombolytic therapy, microbial fibrinolytic enzymes are now much more accepted. The physiochemical properties of this enzyme is becoming well characterized and its effectiveness in thrombolysis in vivo has been further identified.6,7

Nattokinase Benefits & Blood Clots

Blood clots (thrombi) form when strands of fibrin accumulate in the circulatory system. These clots can cause blockage of blood flow. If blood flow is blocked, the oxygen supply to that tissue is cut off and it eventually dies. In the heart, this can result in myocardial infarction (heart attack). In the brain, it can result in strokes or mini-strokes. Deep vein thrombosis can result in pulmonary emboli. All these events can be life-threatening. An in vitro study not only demonstrated the powerful fibrinolytic activity of nattokinase, but also showed the significant reduction in the aggregation of red blood cells and overall lowered whole blood viscosity. The net results are vascular conditions that are less likely to produce blood clots. The authors suggest that nattokinase possesses very real potential as a therapeutic agent in cardiovascular health.8

The process of forming a clot is complex and involves several enzymes. However, the body mainly produces one central enzyme for dissolving a clot, plasmin. It happens that the properties of nattokinase are very similar to plasmin. Nattokinase is particularly effective because it enhances the body's natural ability to fight blood clots in several different ways. It dissolves fibrin directly and appears to enhance the body's natural production of both plasmin and other clot-dissolving enzymes like urokinase. An in vivo study was undertaken to demonstrate the thrombolytic activity of nattokinase, plasmin and elastase on an induced clot in the common carotid artery of laboratory rats. A review of the results indicates that the thrombolytic activity of nattokinase is stronger than that of plasmin or elastase in vivo in this model.9

A fascinating study was conducted to measure the effect of nattokinase in the prevention of deep vein thrombosis and superficial vein thrombosis on extended flights of 7-8 hours on high-risk individuals. The nattokinase group had no thromboses. The placebo group had 5 deep vein thromboses and 2 superficial vein thromboses or 7.6% of 94 individuals. After the flight, the degree of edema was increased by 12% in the placebo group and decreased by 15% in the nattokinase group. The authors concluded that nattokinase was effective in reducing thrombotic events and in controlling edema in high-risk subjects on long flights.10

Serrapeptase Benefits and Respiratory Health

When it comes to the respiratory system, we are constantly at risk of developing health problems, anywhere from the common cold to severe lung diseases. While the cause of any given condition may differ, often time symptoms can manifest themselves and be addressed in similar ways. Clinical testing of serrapeptase reviews its potential with many aspects of respiratory health.

Serrapeptase is widely used in clinical practice in Japan. One research trial in Japan investigated the effect of serrapeptase on sputum properties and symptoms in patients with chronic airway diseases. After 4 weeks of serrapeptase treatment, sputum output, viscosity and sputum neutrophil count decreased significantly. In addition, the frequency of coughing and of expectoration also decreased. The researchers concluded serrapeptase may exert a beneficial effect on mucus clearance by reducing neutrophil numbers and altering the viscoelasticity of sputum in patients with chronic airway diseases.11

Another clinical study reviwed the effect of serrapeptase on the elasticity and viscosity of the nasal mucus in adult patients with chronic sinusitis. Serrapeptase was administered orally for 4 weeks. The dynamic viscosity of the mucus at week 4 was significantly lower than that at week 0. The authors conclude that serrapeptase may have some application in patients with chronic sinusitis.12

The efficacy of serrapeptase was evaluated in a multicentre, double-blind, placebo-controlled study of 193 subjects suffering from acute or chronic ear, nose or throat disorders. After 3-4 days' treatment, significant symptom regression was observed in serrapeptase treated patients. Statistical comparison confirmed the greater efficacy of serrapeptase against all the symptoms examined. It was concluded that serrapeptase has anti-edemic and fibrinolytic activity and supports the body’s healthy response to inflammation.13

Enzyme Stabilization with BPPS®

The Bioactive Protein Peptides System® (BPPS) is a system of peptides used to stabilize and enhance the activity of enzymes.

The Bioactive Protein Peptides System was developed by Specialty Enzymes and Biotechnologies specifically for enzyme stability. Stabilizers have been used since we began manufacturing enzymes in 1957. The BPPS system was a significant advancement developed by Specialty Enzymes in the early 1990's.

It is true it was not trademarked until 2008, but it was in use long before. The reality is, a pure enzyme is not stable. It requires the addition of stabilizers in order to provide a reasonable shelf life. Because we are the actual manufacturer of enzymes with more than 50 years of manufacturing experience, our research and development team constantly works to improve stability and tolerance to the environments in which the enzymes interact. Marketing companies, on the other hand, will generally have significantly less understanding of the physio-chemical and kinetic properties of enzymes.

4/22/11 Serracor-NK vs Neprinol Update

AST Enzymes recently learned of false claims, misstatements and misrepresentations by one of our competitors. These claims call into question the business practices of Specialty Enzymes and Biotechnologies and the quality of Serracor-NK.

Specialty Enzymes & Biotechnologies is a major international manufacturer of enzymes for more than 20 industries, including the nutraceutical industry. Vic Rathi, president and founder of Specialty Enzymes, formulated the original Neprinol for Arthur Andrew Medical (AAM). The formula remains the intellectual property of Specialty Enzymes. AAM was not privy to the formula.

Specialty Enzymes manufactured Neprinol and provided AAM with finished bottles, not raw material, between 2004 and late 2008. Specialty Enzymes is certified GMP, and its manufacturing facilities are certified ISO 9001:2000.

  • Specialty Enzymes received no complaints, verbal or in writing, at any point about the quality and efficacy of Neprinol.
  • Specialty Enzymes did not provide any Neprinol product to AAM in 2009, so any complaints or refunds made thereafter were not for its products. A major distributor who worked with AAM at the time says they did not receive any complaints nor requests for refunds, and there was no apology issued to customers.
  • A review of the batches of Neprinol sold during that time shows activity levels were in accordance with AAM’s requests. In addition, the weight of the powder inside the capsules was within the accepted range of label claims and GMP Standards.
  • Initial production and sale of Serracor-NK was the result of feedback from previous Neprinol customers who contacted Specialty Enzymes as the manufacturer, requesting the original formula.

The quality of Specialty Enzymes products and services are evident in the fact that it has been in business for more than 25 years and continues to experience tremendous growth. In fact, in 2010 Specialty Enzymes expanded its manufacturing facilities, adding a new 25,000 square foot building to meet growing manufacturing demands. Thousands of satisfied customers can attest to the quality and efficacy of our products, and the integrity of our business practices.

Specialty Enzymes is an innovator; creating and manufacturing several of the best-selling enzyme supplements on the market today.

Please feel free to call us with questions.

Serracor-NK vs Neprinol® Setting the Record Straight

Specialty Enzymes & Biochemicals (SEB) is a major manufacturer of enzymes, not just a distributor. We manufacture enzymes for more than 20 different industries, including the nutraceutical industry. Our manufacturing facilities are ISO 9001:2000 and GMP certified.

Recently, false claims have been made about the origin and quality of certain products developed and manufactured by SEB. It is important for us to set the record straight so consumers and health practitioners can feel confident about the origin, quality and efficacy of our enzyme products.

Specialty Enzymes formulated the original Neprinol® and Syntol®

Specialty Enzymes formulated the original Neprinol® and Syntol® brand products, which were marketed by Arthur Andrew Medical. From 2004 until late 2008, SEB manufactured and provided finished bottles of Neprinol and Syntol to Arthur Andrew Medical, a nutritional marketing company. These original product formulations are proprietary and the intellectual property of Specialty Enzymes and Biochemicals Company.

Mr. Vic Rathi, formulator and enzymologist for SEB, developed these formulas as well as SEBkinase®, an essential part of the original Neprinol formula. SEB provided Arthur Andrew Medical with finished products, but never the proprietary formulas. Arthur Andrew Medical is an enzyme marketing company. It does not manufacture enzymes. Specialty Enzymes has been manufacturing enzymes for more than 50 years.

SEBkinase is a blend of enteric-coated nattokinase and serrapeptase, which was first introduced in commerce by SEB in 2002. Two years later, in 2004, SEB was contracted to formulate and make finished products for Arthur Andrew Medical and SEBkinase became an integral part of the original formula of Neprinol.

When Arthur Andrew Medical stopped using Mr. Rathi’s original formulation, some of their customers noticed a difference and expressed a preference for the original formula. As a result, Serracor-NK sebkinase was created and promoted under the direction of Advanced Supplemental Therapies (AST), a subsidiary of SEB. Serracor-NK is the original formulation of Neprinol. Any claim that states otherwise is patently false.

Serracor-NK SEBkinase Formula Remains Unchanged

Specialty Enzymes did not change the formula for SEBkinase or the original formula for Neprinol, which is now available from AST as Serracor-NK. A recent claim alleged we lowered the activity of SEBkinase in the original Neprinol formula. This is untrue. Our SEBkinase blend is unchanged since its introduction. The SEBkinase in Serracor-NK is the same as the SEBkinase in the original formulation of Neprinol. Nothing has changed but the name.

Claims of Higher Enzyme Activity do not Equal Greater Effectiveness

Determining enzyme activity is a precise undertaking and can vary depending on the skill of the lab and many other variables. Moreover, enzyme activity levels do not ultimately reveal how enzymes will perform in the body. There is an art to formulating enzyme products. They must be formulated expertly and correctly for maximum results.

Enteric Coated Serrapeptase and Nattokinase

The nattokinase and serrapeptase in SEBkinase are enteric coated. This is important since the low pH of the stomach can de-nature some enzymes, including these nattokinase and serrapeptase. We don’t know if serrapeptase and nattokinase in the current version of Neprinol is enterically coated. As a result, it is possible some activity will be lost in the stomach.

Make an Informed Choice

There are several systemic enzyme products on the market today. In this case, there are two alternatives: an enzyme product from an expert manufacturer or one from a marketing company. You deserve the highest quality and most effective enzyme products available. We encourage you to make an informed choice.

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